DegronMD - Q13522(PPP1R1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R30Q	TCGA-92-7340	LUSC	TCGA	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30Q	DO26775	LUSC	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30Q	DO222644	MELA	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	TCGA-AN-A046	BRCA	TCGA	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	TCGA-EI-6917	READ	TCGA	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	DO1285	BRCA	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	DO36881	READ	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	SIDM01588	Endometrial Carcinoma	GDSC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.R30W	ACH-000993	Endometrial/Uterine Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1111
p.A26V	TCGA-KN-8434	KICH	TCGA	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.A26V	DO220519	KICH	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.H20Q	DO228952	LICA	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.7582
p.P19T	DO50678	ORCA	ICGC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.7031
p.P19S	SIDM01265	Plasma Cell Myeloma	GDSC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.6752
p.E24D	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2778
p.H20Y	ACH-000378	Lung Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.6118
p.A26E	ACH-000912	Lung Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.R31M	ACH-000985	Colon/Colorectal Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0833

Kaplan plot for PPP1R1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R1A

UniProt ID: Q13522

Entrez ID: 5502

Protein name: Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R1A in