DegronMD

Uniprot ID: Q13522

Source protein: Protein phosphatase 1 regulatory subunit 1A

Source gene: PPP1R1A

Class: LIG_APCC_ABBA_1

Location: 17:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9826

ASA_SCORE: 80.8167

COIL: 0.8958

CONS_SCORE: 0.8063

DSS_SCORE: 0.5355

HELIX: 0.0373

FCONS_SCORE: 0.9175

RIG_SCORE: 0.7189

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H20Q	DO228952	LICA	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.7582
p.P19T	DO50678	ORCA	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.7031
p.P19S	SIDM01265	Plasma Cell Myeloma	GDSC	LEPHLD	LIG_APCC_ABBA_1	0.6752
p.H20Y	ACH-000378	Lung Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	0.6118
p.E24D	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LEPHLD	LIG_APCC_ABBA_1	0.2778
p.A26V	TCGA-KN-8434	KICH	TCGA	LEPHLD	LIG_APCC_ABBA_1	0.2222
p.A26V	DO220519	KICH	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.2222
p.A26E	ACH-000912	Lung Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	0.2222
p.R30Q	TCGA-92-7340	LUSC	TCGA	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30Q	DO26775	LUSC	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30Q	DO222644	MELA	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	TCGA-AN-A046	BRCA	TCGA	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	TCGA-EI-6917	READ	TCGA	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	DO1285	BRCA	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	DO36881	READ	ICGC	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	SIDM01588	Endometrial Carcinoma	GDSC	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R30W	ACH-000993	Endometrial/Uterine Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	0.1111
p.R31M	ACH-000985	Colon/Colorectal Cancer	CCLE	LEPHLD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13522	Protein phosphatase 1 regulatory subunit 1A	LIG_APCC_ABBA_1	17:22	LEPHLD	APC,CDC20,FZR1	0.9826	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons