DegronMD - Q13562(NEUROD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E254K	TCGA-85-A4CL	LUSC	TCGA	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.591
p.E254K	DO45454	LUSC	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.591
p.T265S	TCGA-AF-3913	READ	TCGA	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.T265S	DO36846	READ	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.A252T	TCGA-EO-A22X	UCEC	TCGA	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.3056
p.A252T	DO43907	UCEC	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.3056
p.D263E	TCGA-EW-A1PG	BRCA	TCGA	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1944
p.D263E	DO3698	BRCA	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1944
p.A251T	TCGA-F5-6814	READ	TCGA	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.2778
p.A251T	DO233156	GACA	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.2778
p.A251T	DO36556	READ	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.2778
p.H247Q	DO228952	LICA	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1667
p.Y249H	DO48761	LIRI	ICGC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.2222
p.P246Q	SIDM00653	Small Cell Lung Carcinoma	GDSC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.P246Q	ACH-000514	Lung Cancer	CCLE	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.P246Q	NCI-H1092	lung	COSMIC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.P255H	SIDM00927	Small Cell Lung Carcinoma	GDSC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.7694
p.P255H	ACH-000871	Lung Cancer	CCLE	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.7694
p.P255H	NCI-H510A	lung	COSMIC	LEPFFE	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.7694

Kaplan plot for NEUROD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEUROD1

UniProt ID: Q13562

Entrez ID: 4760

Protein name: Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEUROD1 in