DegronMD

Uniprot ID: Q13562

Source protein: Neurogenic differentiation factor 1

Source gene: NEUROD1

Class: LIG_APCC_ABBA_1

Location: 253:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9645

ASA_SCORE: 68.5

COIL: 0.7567

CONS_SCORE: 0.3782

DSS_SCORE: 0.3832

HELIX: 0.1667

FCONS_SCORE: 1.0765

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E254K	TCGA-85-A4CL	LUSC	TCGA	LEPFFE	LIG_APCC_ABBA_1	0.591
p.E254K	DO45454	LUSC	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.591
p.T265S	TCGA-AF-3913	READ	TCGA	LEPFFE	LIG_APCC_ABBA_1	0.1389
p.T265S	DO36846	READ	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.1389
p.A252T	TCGA-EO-A22X	UCEC	TCGA	LEPFFE	LIG_APCC_ABBA_1	0.3056
p.A252T	DO43907	UCEC	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.3056
p.D263E	TCGA-EW-A1PG	BRCA	TCGA	LEPFFE	LIG_APCC_ABBA_1	0.1944
p.D263E	DO3698	BRCA	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.1944
p.A251T	TCGA-F5-6814	READ	TCGA	LEPFFE	LIG_APCC_ABBA_1	0.2778
p.A251T	DO233156	GACA	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.2778
p.A251T	DO36556	READ	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.2778
p.H247Q	DO228952	LICA	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.1667
p.Y249H	DO48761	LIRI	ICGC	LEPFFE	LIG_APCC_ABBA_1	0.2222
p.P246Q	SIDM00653	Small Cell Lung Carcinoma	GDSC	LEPFFE	LIG_APCC_ABBA_1	0.1389
p.P246Q	ACH-000514	Lung Cancer	CCLE	LEPFFE	LIG_APCC_ABBA_1	0.1389
p.P246Q	NCI-H1092	lung	COSMIC	LEPFFE	LIG_APCC_ABBA_1	0.1389
p.P255H	SIDM00927	Small Cell Lung Carcinoma	GDSC	LEPFFE	LIG_APCC_ABBA_1	0.7694
p.P255H	ACH-000871	Lung Cancer	CCLE	LEPFFE	LIG_APCC_ABBA_1	0.7694
p.P255H	NCI-H510A	lung	COSMIC	LEPFFE	LIG_APCC_ABBA_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13562	Neurogenic differentiation factor 1	LIG_APCC_ABBA_1	253:258	LEPFFE	APC,CDC20,FZR1	0.9645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons