DegronMD - Q13591(SEMA5A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H418Y	TCGA-86-8054	LUAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6118
p.H418Y	DO23923	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6118
p.H418Y	DO222875	MELA	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6118
p.T428I	TCGA-A5-A1OF	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1111
p.T428I	DO42568	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1111
p.D408N	TCGA-AP-A056	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2222
p.D408N	DO233732	GACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2222
p.D408N	DO43971	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2222
p.G427R	TCGA-AP-A0LM	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.G427R	TCGA-BR-8372	STAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.G427R	DO47873	STAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.G427R	DO43306	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.G427R	SIDM01274	Esophageal Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.V410L	TCGA-L9-A7SV	LUAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2778
p.V410L	DO49875	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2778
p.K430T	DO50438	ESAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation substituting flanking lysine	0.1667
p.Q411P	DO233882	GACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.3056
p.G412A	DO25104	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6429
p.V409L	DO232852	NACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.25
p.A423T	DO233295	NACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.25
p.V405M	SIDM00928	Breast Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.V405M	CAL-85-1	breast	COSMIC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1389
p.V417A	SIDM01042	Breast Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.5825
p.V417A	EVSA-T	breast	COSMIC	GREALVHII	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.5825

Kaplan plot for SEMA5A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA5A

UniProt ID: Q13591

Entrez ID: 9037

Protein name: Semaphorin-5A (Semaphorin-F) (Sema F)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA5A in