DegronMD

Uniprot ID: Q13591

Source protein: Semaphorin-5A

Source gene: SEMA5A

Class: DEG_APCC_DBOX_1

Location: 412:420

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5828

ASA_SCORE: 53.5778

COIL: 0.4702

CONS_SCORE: 0.4489

DSS_SCORE: 0.0349

HELIX: 0.0257

FCONS_SCORE: 0.7243

RIG_SCORE: 0.9192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H418Y	TCGA-86-8054	LUAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.6118
p.H418Y	DO23923	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.6118
p.H418Y	DO222875	MELA	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.6118
p.T428I	TCGA-A5-A1OF	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.1111
p.T428I	DO42568	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.1111
p.D408N	TCGA-AP-A056	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.2222
p.D408N	DO233732	GACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.2222
p.D408N	DO43971	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.2222
p.G427R	TCGA-AP-A0LM	UCEC	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.G427R	TCGA-BR-8372	STAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.G427R	DO47873	STAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.G427R	DO43306	UCEC	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.G427R	SIDM01274	Esophageal Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.V410L	TCGA-L9-A7SV	LUAD	TCGA	GREALVHII	DEG_APCC_DBOX_1	0.2778
p.V410L	DO49875	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.2778
p.K430T	DO50438	ESAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.1667
p.Q411P	DO233882	GACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.3056
p.G412A	DO25104	LUAD	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.6429
p.V409L	DO232852	NACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.25
p.A423T	DO233295	NACA	ICGC	GREALVHII	DEG_APCC_DBOX_1	0.25
p.V405M	SIDM00928	Breast Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.V405M	CAL-85-1	breast	COSMIC	GREALVHII	DEG_APCC_DBOX_1	0.1389
p.V417A	SIDM01042	Breast Carcinoma	GDSC	GREALVHII	DEG_APCC_DBOX_1	0.5825
p.V417A	EVSA-T	breast	COSMIC	GREALVHII	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13591	Semaphorin-5A	DEG_APCC_DBOX_1	412:420	GREALVHII	APC,CDC20,FZR1	0.5828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons