MTMR2
UniProt ID: Q13614
Entrez ID: 8898
Protein name: Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosph...
FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139}.
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GO - Biological processes (BP):
dendritic spine maintenance [GO:0097062]; inositol phosphate dephosphorylation [GO:0046855]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative...
dendritic spine maintenance [GO:0097062]; inositol phosphate dephosphorylation [GO:0046855]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphatase activity [GO:0004438]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]...
identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphatase activity [GO:0004438]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]
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GO - Cellular component (CC):
axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm...
axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774]
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MTMR2
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*NOTE: the Kaplan plots were collected from OncoLnc