DegronMD - Q13634(CDH18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V234I	TCGA-13-1500	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V234I	TCGA-D1-A1O7	UCEC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V234I	DO230342	COCA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V234I	DO233876	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V234I	DO29698	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V234I	DO41139	UCEC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.E227K	TCGA-29-1763	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2778
p.E227K	DO28422	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2778
p.R218K	TCGA-29-1763	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.7237
p.R218K	DO28422	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.7237
p.H222L	TCGA-34-2600	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6202
p.H222L	DO27081	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6202
p.D225E	TCGA-51-4080	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.5647
p.D225E	DO26441	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.5647
p.H231Q	TCGA-95-7039	LUAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.H231Q	DO23907	LUAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211N	TCGA-AA-3984	COAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211N	DO9002	COAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211N	SIDM00668	Non-Cancerous	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211N	ACH-002245	Lymphoma	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211N	Hs-445	haematopoietic and lymphoid tissue	COSMIC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.V210I	TCGA-CD-8531	STAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.V210I	TCGA-VS-A9UL	CESC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.V210I	TCGA-YZ-A985	UVM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.V210I	DO51643	CESC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.V210I	DO10486	COAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.V210I	DO47877	STAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1389
p.D211Y	TCGA-CV-5978	HNSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.D211Y	DO16023	HNSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.R226K	TCGA-ER-A193	SKCM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.3056
p.R226K	DO47368	SKCM	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.3056
p.E230K	TCGA-FR-A726	SKCM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.E230K	DO48665	SKCM	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.E230K	SIDM00528	Breast Carcinoma	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.E230K	ACH-000934	Breast Cancer	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.E230K	MDA-MB-361	breast	COSMIC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.R229I	TCGA-O2-A52N	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2222
p.R229I	DO233869	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2222
p.R229I	DO219217	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2222
p.T219M	TCGA-YL-A8HL	PRAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6312
p.T219M	DO51418	PRAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6312
p.T219M	SIDM01729	Endometrial Carcinoma	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6312
p.T219M	ACH-000909	Endometrial/Uterine Cancer	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6312
p.R218I	DO233145	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.8102
p.H231N	DO228986	LICA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1667
p.G215E	DO218861	SKCA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.2778

Kaplan plot for CDH18 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH18

UniProt ID: Q13634

Entrez ID: 1016

Protein name: Cadherin-18 (Cadherin-14)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDH18 in