DegronMD

Uniprot ID: Q13634

Source protein: Cadherin-18

Source gene: CDH18

Class: DEG_APCC_DBOX_1

Location: 217:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8832

ASA_SCORE: 51.1

COIL: 0.553

CONS_SCORE: 0.7924

DSS_SCORE: 0.3894

HELIX: 0.0172

FCONS_SCORE: 0.9734

RIG_SCORE: 0.8218

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V234I	TCGA-13-1500	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.V234I	TCGA-D1-A1O7	UCEC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.V234I	DO230342	COCA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.V234I	DO233876	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.V234I	DO29698	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.V234I	DO41139	UCEC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.0833
p.E227K	TCGA-29-1763	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.2778
p.E227K	DO28422	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.2778
p.R218K	TCGA-29-1763	OV	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.7237
p.R218K	DO28422	OV	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.7237
p.H222L	TCGA-34-2600	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.6202
p.H222L	DO27081	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.6202
p.D225E	TCGA-51-4080	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.5647
p.D225E	DO26441	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.5647
p.H231Q	TCGA-95-7039	LUAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.H231Q	DO23907	LUAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211N	TCGA-AA-3984	COAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211N	DO9002	COAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211N	SIDM00668	Non-Cancerous	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211N	ACH-002245	Lymphoma	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211N	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.V210I	TCGA-CD-8531	STAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.V210I	TCGA-VS-A9UL	CESC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.V210I	TCGA-YZ-A985	UVM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.V210I	DO51643	CESC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.V210I	DO10486	COAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.V210I	DO47877	STAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1389
p.D211Y	TCGA-CV-5978	HNSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.D211Y	DO16023	HNSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.R226K	TCGA-ER-A193	SKCM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.3056
p.R226K	DO47368	SKCM	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.3056
p.E230K	TCGA-FR-A726	SKCM	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.1944
p.E230K	DO48665	SKCM	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1944
p.E230K	SIDM00528	Breast Carcinoma	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	0.1944
p.E230K	ACH-000934	Breast Cancer	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	0.1944
p.E230K	MDA-MB-361	breast	COSMIC	IRTALHNMD	DEG_APCC_DBOX_1	0.1944
p.R229I	TCGA-O2-A52N	LUSC	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.2222
p.R229I	DO233869	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.2222
p.R229I	DO219217	LUSC	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.2222
p.T219M	TCGA-YL-A8HL	PRAD	TCGA	IRTALHNMD	DEG_APCC_DBOX_1	0.6312
p.T219M	DO51418	PRAD	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.6312
p.T219M	SIDM01729	Endometrial Carcinoma	GDSC	IRTALHNMD	DEG_APCC_DBOX_1	0.6312
p.T219M	ACH-000909	Endometrial/Uterine Cancer	CCLE	IRTALHNMD	DEG_APCC_DBOX_1	0.6312
p.R218I	DO233145	GACA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.8102
p.H231N	DO228986	LICA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.1667
p.G215E	DO218861	SKCA	ICGC	IRTALHNMD	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRTALHNMD

Degron related mutations and impact score

Drug responses associated with CDH18 mutations

All proteins holding degron of IRTALHNMD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13634	Cadherin-18	DEG_APCC_DBOX_1	217:225	IRTALHNMD	APC,CDC20,FZR1	0.8832	More...