IL10RA
UniProt ID: Q13651
Entrez ID: 3587
Protein name: Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). ...
FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). {ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:26962683}.
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GO - Biological processes (BP):
cytokine-mediated signaling pathway [GO:0019221]; negative regulation of autophagy [GO:0010507]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of synapse organization [GO:0050807]; response to lipopolysaccharide [GO:0032496]; ubiquitin-dependent endocytosis ...
cytokine-mediated signaling pathway [GO:0019221]; negative regulation of autophagy [GO:0010507]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of synapse organization [GO:0050807]; response to lipopolysaccharide [GO:0032496]; ubiquitin-dependent endocytosis [GO:0070086]
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GO - Molecular function (MF):
cytokine receptor activity [GO:0004896]; interleukin-10 binding [GO:0019969]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]...
cytokine receptor activity [GO:0004896]; interleukin-10 binding [GO:0019969]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023]
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GO - Cellular component (CC):
cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]...
cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]
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IL10RA
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Kaplan plot for IL10RA in
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*NOTE: the Kaplan plots were collected from OncoLnc