DegronMD

Uniprot ID: Q13651

Source protein: Interleukin-10 receptor subunit alpha

Source gene: IL10RA

Class: DEG_SCF_TRCP1_1

Location: 318:324

E3 ligase: BTRC

DEGRON score: 0.9949

ASA_SCORE: 80.1286

COIL: 0.9363

CONS_SCORE: 0.514

DSS_SCORE: 0.6736

HELIX: 0.0344

FCONS_SCORE: 1.0326

RIG_SCORE: 0.5766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P326T	TCGA-49-AARQ	LUAD	TCGA	DSGFGST	DEG_SCF_TRCP1_1	0.2778
p.Q329K	TCGA-4G-AAZO	CHOL	TCGA	DSGFGST	DEG_SCF_TRCP1_1	0.1944
p.N310S	TCGA-EE-A29E	SKCM	TCGA	DSGFGST	DEG_SCF_TRCP1_1	0.1111
p.N310S	SIDM00150	Colorectal Carcinoma	GDSC	DSGFGST	DEG_SCF_TRCP1_1	0.1111
p.N310S	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGFGST	DEG_SCF_TRCP1_1	0.1111
p.N310S	KM12	large_intestine	COSMIC	DSGFGST	DEG_SCF_TRCP1_1	0.1111
p.G320D	TCGA-F5-6814	READ	TCGA	DSGFGST	DEG_SCF_TRCP1_1	0.7198
p.L313M	TCGA-FS-A1ZU	SKCM	TCGA	DSGFGST	DEG_SCF_TRCP1_1	0.1944
p.D334G	DO9490	COAD	ICGC	DSGFGST	DEG_SCF_TRCP1_1	0.0556
p.P319S	DO233642	GACA	ICGC	DSGFGST	DEG_SCF_TRCP1_1	0.6752
p.L320F	DO23524	LIRI	ICGC	DSGFGST	DEG_SCF_TRCP1_1	0.6981
p.G329E	DO37406	SKCM	ICGC	DSGFGST	DEG_SCF_TRCP1_1	0.1944
p.G312C	DO42953	UCEC	ICGC	DSGFGST	DEG_SCF_TRCP1_1	0.1667
p.S316G	SIDM00391	Plasma Cell Myeloma	GDSC	DSGFGST	DEG_SCF_TRCP1_1	0.2778
p.S316G	ACH-000363	Myeloma	CCLE	DSGFGST	DEG_SCF_TRCP1_1	0.2778
p.S316G	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFGST	DEG_SCF_TRCP1_1	0.2778
p.H314Y	SIDM00783	Colorectal Carcinoma	GDSC	DSGFGST	DEG_SCF_TRCP1_1	0.2222
p.H314Y	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGFGST	DEG_SCF_TRCP1_1	0.2222
p.H314Y	HCT-116	large_intestine	COSMIC	DSGFGST	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13651	Interleukin-10 receptor subunit alpha	DEG_SCF_TRCP1_1	318:324	DSGFGST	BTRC	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons