DegronMD - Q13671(RIN1)

RIN1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S333N	TCGA-A6-6649	COAD	TCGA	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation blocking phosphorylation signal	0.5
p.S333N	DO9186	COAD	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation blocking phosphorylation signal	0.5
p.R344Q	TCGA-EI-6507	READ	TCGA	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7329
p.R344Q	DO36675	READ	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7329
p.P338T	DO50909	LICA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.A352T	DO231728	LINC	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.A352T	DO27120	LUSC	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.S351N	DO229264	THCA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7069
p.R343Q	DO229201	THCA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6218
p.Y357C	ACH-002847	Unknown	CCLE	RRPLLRSMS	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc