DegronMD

Uniprot ID: Q13671

Source protein: Ras and Rab interactor 1

Source gene: RIN1

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8079

ASA_SCORE: 85.5

COIL: 0.5987

CONS_SCORE: 0.5201

DSS_SCORE: 0.3881

HELIX: 0.3553

FCONS_SCORE: 0.9784

RIG_SCORE: 0.7382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S333N	TCGA-A6-6649	COAD	TCGA	RRPLLRSMS	DEG_APCC_DBOX_1	0.5
p.S333N	DO9186	COAD	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.5
p.R344Q	TCGA-EI-6507	READ	TCGA	RRPLLRSMS	DEG_APCC_DBOX_1	0.7329
p.R344Q	DO36675	READ	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.7329
p.P338T	DO50909	LICA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.1944
p.A352T	DO231728	LINC	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.3056
p.A352T	DO27120	LUSC	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.3056
p.S351N	DO229264	THCA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.7069
p.R343Q	DO229201	THCA	ICGC	RRPLLRSMS	DEG_APCC_DBOX_1	0.6218
p.Y357C	ACH-002847	Unknown	CCLE	RRPLLRSMS	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13671	Ras and Rab interactor 1	DEG_APCC_DBOX_1	343:351	RRPLLRSMS	APC,CDC20,FZR1	0.8079	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons