DegronMD - Q13733(ATP1A4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T81S	TCGA-05-4415	LUAD	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1389
p.T81S	DO25747	LUAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1389
p.E78K	TCGA-18-3409	LUSC	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.E78K	TCGA-EE-A3JD	SKCM	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.E78K	DO26444	LUSC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.E78K	DO220895	MELA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.E78K	DO222749	MELA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.E78K	DO50299	SKCM	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.0556
p.F100C	TCGA-67-6215	LUAD	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1389
p.F100C	DO25068	LUAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1389
p.K99T	TCGA-AX-A05Z	UCEC	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation substituting flanking lysine	0.2778
p.K99T	DO40884	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation substituting flanking lysine	0.2778
p.G84R	TCGA-DX-A1L0	SARC	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.2222
p.G84R	DO219949	SARC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.2222
p.K102T	TCGA-EO-A22X	UCEC	TCGA	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation substituting flanking lysine	0.1944
p.K102T	DO43907	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation substituting flanking lysine	0.1944
p.R82C	DO474	BLCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1667
p.R83C	DO8018	COAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.R83C	DO23538	LIRI	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.V95I	DO52457	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.2778
p.G83D	DO229010	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO229013	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO229016	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO229003	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO229005	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO225404	LAML	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G83D	DO52365	LUSC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.G84V	DO229026	LICA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.2222
p.V88D	DO233298	NACA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation altering degron motif	0.7785
p.P92L	DO218280	ORCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation altering degron motif	0.6471
p.L96I	DO38111	SKCM	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.25
p.R83H	DO38328	STAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.V98G	DO229275	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.V98G	DO229216	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1944
p.T93P	DO229275	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation altering degron motif	0.7031
p.R82H	DO43073	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation rewiring degron network	0.1667
p.E102K	NCI-H1915	lung	COSMIC	VTPPPT	DEG_SCF_FBW7_1	88:93	Mutation substituting flanking lysine	0.1944

Kaplan plot for ATP1A4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP1A4

UniProt ID: Q13733

Entrez ID: 480

Protein name: Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ATP1A4 in