DegronMD

Uniprot ID: Q13733

Source protein: Sodium/potassium-transporting ATPase subunit alpha-4

Source gene: ATP1A4

Class: DEG_SCF_FBW7_1

Location: 88:93

E3 ligase: FBXW7

DEGRON score: 0.8847

ASA_SCORE: 83.2833

COIL: 0.9107

CONS_SCORE: 0.4989

DSS_SCORE: 0.4914

HELIX: 0.0087

FCONS_SCORE: 1.1381

RIG_SCORE: 0.6923

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T81S	TCGA-05-4415	LUAD	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.1389
p.T81S	DO25747	LUAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1389
p.E78K	TCGA-18-3409	LUSC	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.E78K	TCGA-EE-A3JD	SKCM	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.E78K	DO26444	LUSC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.E78K	DO220895	MELA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.E78K	DO222749	MELA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.E78K	DO50299	SKCM	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.0556
p.F100C	TCGA-67-6215	LUAD	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.1389
p.F100C	DO25068	LUAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1389
p.K99T	TCGA-AX-A05Z	UCEC	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.2778
p.K99T	DO40884	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.2778
p.G84R	TCGA-DX-A1L0	SARC	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.2222
p.G84R	DO219949	SARC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.2222
p.K102T	TCGA-EO-A22X	UCEC	TCGA	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.K102T	DO43907	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.R82C	DO474	BLCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1667
p.R83C	DO8018	COAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.R83C	DO23538	LIRI	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.V95I	DO52457	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.2778
p.G83D	DO229010	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO229013	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO229016	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO229003	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO229005	COCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO225404	LAML	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G83D	DO52365	LUSC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.G84V	DO229026	LICA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.2222
p.V88D	DO233298	NACA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.7785
p.P92L	DO218280	ORCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.6471
p.L96I	DO38111	SKCM	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.25
p.R83H	DO38328	STAD	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.V98G	DO229275	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.V98G	DO229216	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1944
p.T93P	DO229275	THCA	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.7031
p.R82H	DO43073	UCEC	ICGC	VTPPPT	DEG_SCF_FBW7_1	0.1667
p.E102K	NCI-H1915	lung	COSMIC	VTPPPT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPPPT

Degron related mutations and impact score

Drug responses associated with ATP1A4 mutations

All proteins holding degron of VTPPPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13733	Sodium/potassium-transporting ATPase subunit alpha-4	DEG_SCF_FBW7_1	88:93	VTPPPT	FBXW7	0.8847	More...