DegronMD - Q13740(ALCAM)

FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G414V	TCGA-49-6767	LUAD	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.2778
p.G414V	DO23586	LUAD	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.2778
p.T409A	TCGA-B5-A11N	UCEC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6028
p.T409A	DO41458	UCEC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6028
p.Q397H	TCGA-B5-A1MX	UCEC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.Q397H	DO41999	UCEC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.E398G	TCGA-BR-8487	STAD	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1667
p.E398G	DO47867	STAD	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1667
p.E406K	TCGA-DA-A1HW	SKCM	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.591
p.E406K	DO38129	SKCM	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.591
p.K403N	TCGA-FU-A23L	CESC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056
p.K403N	DO6278	CESC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056
p.M420I	DO217896	GACA	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1111
p.E406D	ACH-001057	Lymphoma	CCLE	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5647
p.E410K	SW684	soft tissue	COSMIC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7022
p.G416V	CW-2	large intestine	COSMIC	KRESLTLIV	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.2222

Kaplan plot for ALCAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALCAM

UniProt ID: Q13740

Entrez ID: 214

Protein name: CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALCAM in