DegronMD

Uniprot ID: Q13740

Source protein: CD166 antigen

Source gene: ALCAM

Class: DEG_APCC_DBOX_1

Location: 404:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7334

ASA_SCORE: 54.7778

COIL: 0.138

CONS_SCORE: 0.6125

DSS_SCORE: 0.3174

HELIX: 0.0072

FCONS_SCORE: 1.0216

RIG_SCORE: 0.8372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G414V	TCGA-49-6767	LUAD	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.2778
p.G414V	DO23586	LUAD	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.2778
p.T409A	TCGA-B5-A11N	UCEC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.6028
p.T409A	DO41458	UCEC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.6028
p.Q397H	TCGA-B5-A1MX	UCEC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.1389
p.Q397H	DO41999	UCEC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.1389
p.E398G	TCGA-BR-8487	STAD	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.1667
p.E398G	DO47867	STAD	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.1667
p.E406K	TCGA-DA-A1HW	SKCM	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.591
p.E406K	DO38129	SKCM	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.591
p.K403N	TCGA-FU-A23L	CESC	TCGA	KRESLTLIV	DEG_APCC_DBOX_1	0.3056
p.K403N	DO6278	CESC	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.3056
p.M420I	DO217896	GACA	ICGC	KRESLTLIV	DEG_APCC_DBOX_1	0.1111
p.E406D	ACH-001057	Lymphoma	CCLE	KRESLTLIV	DEG_APCC_DBOX_1	0.5647
p.E410K	SW684	soft_tissue	COSMIC	KRESLTLIV	DEG_APCC_DBOX_1	0.7022
p.G416V	CW-2	large_intestine	COSMIC	KRESLTLIV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13740	CD166 antigen	DEG_APCC_DBOX_1	404:412	KRESLTLIV	APC,CDC20,FZR1	0.7334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons