DegronMD - Q13772(NCOA4)

NCOA4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S296F	TCGA-AZ-4315	COAD	TCGA	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.0833
p.S298F	TCGA-NC-A5HN	LUSC	TCGA	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.E318G	DO222421	BTCA	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.N319K	DO52115	HNSC	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1111
p.R315W	DO48555	LIHC	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2222
p.E318Q	DO23555	LUAD	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.S311F	DO36353	PRAD	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.7982
p.Q309H	DO37707	SKCM	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.647
p.H312N	DO37966	SKCM	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.3056
p.R315Q	DO43306	UCEC	ICGC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2222
p.E314V	SIDM01074	Glioblastoma	GDSC	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.25
p.T307I	ACH-000288	Breast Cancer	CCLE	LVTPQES	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.8189

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*NOTE: the Kaplan plots were collected from OncoLnc