DegronMD

Uniprot ID: Q13772

Source protein: Nuclear receptor coactivator 4

Source gene: NCOA4

Class: DEG_SCF_FBW7_1

Location: 305:311

E3 ligase: FBXW7

DEGRON score: 0.9662

ASA_SCORE: 71.4571

COIL: 0.6841

CONS_SCORE: 0.467

DSS_SCORE: 0.5471

HELIX: 0.2731

FCONS_SCORE: 1.1292

RIG_SCORE: 0.7297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S296F	TCGA-AZ-4315	COAD	TCGA	LVTPQES	DEG_SCF_FBW7_1	0.0833
p.S298F	TCGA-NC-A5HN	LUSC	TCGA	LVTPQES	DEG_SCF_FBW7_1	0.1389
p.E318G	DO222421	BTCA	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.1389
p.N319K	DO52115	HNSC	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.1111
p.R315W	DO48555	LIHC	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.2222
p.E318Q	DO23555	LUAD	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.1389
p.S311F	DO36353	PRAD	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.7982
p.Q309H	DO37707	SKCM	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.647
p.H312N	DO37966	SKCM	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.3056
p.R315Q	DO43306	UCEC	ICGC	LVTPQES	DEG_SCF_FBW7_1	0.2222
p.E314V	SIDM01074	Glioblastoma	GDSC	LVTPQES	DEG_SCF_FBW7_1	0.25
p.T307I	ACH-000288	Breast Cancer	CCLE	LVTPQES	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13772	Nuclear receptor coactivator 4	DEG_SCF_FBW7_1	305:311	LVTPQES	FBXW7	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons