DegronMD - Q13813(SPTAN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2460K	TCGA-A5-A0G1	UCEC	TCGA	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0556
p.E2460K	DO42472	UCEC	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0556
p.C2446W	TCGA-AA-3713	COAD	TCGA	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation altering degron motif	0.7
p.C2446W	DO8400	COAD	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation altering degron motif	0.7
p.G2456C	TCGA-D3-A2JL	SKCM	TCGA	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.1667
p.G2456C	DO47278	SKCM	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.1667
p.R2440Q	TCGA-OR-A5KB	ACC	TCGA	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation blocking phosphorylation signal	0.6389
p.R2459H	DO233089	GACA	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0833
p.V2442I	DO233205	GACA	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.25
p.E2460D	DO229009	LICA	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0556
p.D2444Y	DO50751	LICA	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.3056
p.A2438V	DO222837	MELA	ICGC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.1389
p.S2443N	SIDM00945	Colorectal Carcinoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.2778
p.S2443N	CL-34	large intestine	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.2778
p.E2454K	SIDM01111	Ewing's Sarcoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.2222
p.E2454K	SK-ES-1	bone	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.2222
p.A2441V	SIDM00500	Colorectal Carcinoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.2222
p.D2439N	ACH-000120	Neuroblastoma	CCLE	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.1667
p.D2439N	CHP-212	autonomic ganglia	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.1667
p.F2460L	ACH-000914	Lymphoma	CCLE	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0556
p.F2460L	HT	haematopoietic and lymphoid tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.0556
p.M2445T	ACH-000994	Endometrial/Uterine Cancer	CCLE	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation altering degron motif	0.7423
p.F2440L	HT	haematopoietic and lymphoid tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation blocking phosphorylation signal	0.6389
p.D2444N	CHP-212	autonomic ganglia	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation rewiring degron network	0.3056
p.F2445L	HT	haematopoietic and lymphoid tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	2445:2450	Mutation altering degron motif	0.6981

Kaplan plot for SPTAN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTAN1

UniProt ID: Q13813

Entrez ID: 6709

Protein name: Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTAN1 in