DegronMD

Uniprot ID: Q13813

Source protein: Spectrin alpha chain, non-erythrocytic 1

Source gene: SPTAN1

Class: LIG_APCC_ABBA_1

Location: 2445:2450

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6355

ASA_SCORE: 63.8

COIL: 0.423

CONS_SCORE: 0.6674

DSS_SCORE: 0.2783

HELIX: 0.0428

FCONS_SCORE: 1.0593

RIG_SCORE: 0.7956

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2460K	TCGA-A5-A0G1	UCEC	TCGA	MKPYVD	LIG_APCC_ABBA_1	0.0556
p.E2460K	DO42472	UCEC	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.0556
p.C2446W	TCGA-AA-3713	COAD	TCGA	MKPYVD	LIG_APCC_ABBA_1	0.7
p.C2446W	DO8400	COAD	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.7
p.G2456C	TCGA-D3-A2JL	SKCM	TCGA	MKPYVD	LIG_APCC_ABBA_1	0.1667
p.G2456C	DO47278	SKCM	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.1667
p.R2440Q	TCGA-OR-A5KB	ACC	TCGA	MKPYVD	LIG_APCC_ABBA_1	0.6389
p.R2459H	DO233089	GACA	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.0833
p.V2442I	DO233205	GACA	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.25
p.E2460D	DO229009	LICA	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.0556
p.D2444Y	DO50751	LICA	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.3056
p.A2438V	DO222837	MELA	ICGC	MKPYVD	LIG_APCC_ABBA_1	0.1389
p.S2443N	SIDM00945	Colorectal Carcinoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	0.2778
p.S2443N	CL-34	large_intestine	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.2778
p.E2454K	SIDM01111	Ewing's Sarcoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	0.2222
p.E2454K	SK-ES-1	bone	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.2222
p.A2441V	SIDM00500	Colorectal Carcinoma	GDSC	MKPYVD	LIG_APCC_ABBA_1	0.2222
p.D2439N	ACH-000120	Neuroblastoma	CCLE	MKPYVD	LIG_APCC_ABBA_1	0.1667
p.D2439N	CHP-212	autonomic_ganglia	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.1667
p.F2460L	ACH-000914	Lymphoma	CCLE	MKPYVD	LIG_APCC_ABBA_1	0.0556
p.F2460L	HT	haematopoietic_and_lymphoid_tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.0556
p.M2445T	ACH-000994	Endometrial/Uterine Cancer	CCLE	MKPYVD	LIG_APCC_ABBA_1	0.7423
p.F2440L	HT	haematopoietic_and_lymphoid_tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.6389
p.D2444N	CHP-212	autonomic_ganglia	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.3056
p.F2445L	HT	haematopoietic_and_lymphoid_tissue	COSMIC	MKPYVD	LIG_APCC_ABBA_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13813	Spectrin alpha chain, non-erythrocytic 1	LIG_APCC_ABBA_1	2445:2450	MKPYVD	APC,CDC20,FZR1	0.6355	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MKPYVD

Degron related mutations and impact score

Drug responses associated with SPTAN1 mutations

All proteins holding degron of MKPYVD