DegronMD - Q13823(GNL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E480K	TCGA-29-1784	OV	TCGA	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation altering degron motif	0.591
p.E480K	DO28561	OV	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation altering degron motif	0.591
p.P490S	TCGA-DA-A960	SKCM	TCGA	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.1944
p.P490S	DO219482	SKCM	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.1944
p.Q472E	TCGA-XF-A9T0	BLCA	TCGA	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.2222
p.Q472E	DO51920	BLCA	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.2222
p.P475T	DO229019	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.3056
p.P490T	DO229019	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.1944
p.N488K	DO229028	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.25
p.V494I	SIDM01412	Oral Cavity Carcinoma	GDSC	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.0833
p.V494I	ACH-000762	Head and Neck Cancer	CCLE	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.0833
p.P490A	ACH-000283	Brain Cancer	CCLE	SSSLEVVPEA	DEG_COP1_1	476:485	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons