DegronMD

Uniprot ID: Q13823

Source protein: Nucleolar GTP-binding protein 2

Source gene: GNL2

Class: DEG_COP1_1

Location: 476:485

E3 ligase: COP1

DEGRON score: 0.825

ASA_SCORE: 67.13

COIL: 0.51

CONS_SCORE: 0.2396

DSS_SCORE: 0.5356

HELIX: 0.426

FCONS_SCORE: 0.9849

RIG_SCORE: 0.703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E480K	TCGA-29-1784	OV	TCGA	SSSLEVVPEA	DEG_COP1_1	0.591
p.E480K	DO28561	OV	ICGC	SSSLEVVPEA	DEG_COP1_1	0.591
p.P490S	TCGA-DA-A960	SKCM	TCGA	SSSLEVVPEA	DEG_COP1_1	0.1944
p.P490S	DO219482	SKCM	ICGC	SSSLEVVPEA	DEG_COP1_1	0.1944
p.Q472E	TCGA-XF-A9T0	BLCA	TCGA	SSSLEVVPEA	DEG_COP1_1	0.2222
p.Q472E	DO51920	BLCA	ICGC	SSSLEVVPEA	DEG_COP1_1	0.2222
p.P475T	DO229019	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	0.3056
p.P490T	DO229019	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	0.1944
p.N488K	DO229028	LICA	ICGC	SSSLEVVPEA	DEG_COP1_1	0.25
p.V494I	SIDM01412	Oral Cavity Carcinoma	GDSC	SSSLEVVPEA	DEG_COP1_1	0.0833
p.V494I	ACH-000762	Head and Neck Cancer	CCLE	SSSLEVVPEA	DEG_COP1_1	0.0833
p.P490A	ACH-000283	Brain Cancer	CCLE	SSSLEVVPEA	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13823	Nucleolar GTP-binding protein 2	DEG_COP1_1	476:485	SSSLEVVPEA	COP1	0.825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons