DegronMD - Q13905(RAPGEF1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S376I	TCGA-85-8479	LUSC	TCGA	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.3056
p.R365H	TCGA-AP-A051	UCEC	TCGA	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1944
p.R365H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1944
p.R365H	SIDM00351	Oral Cavity Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1944
p.R365H	TE-11	oesophagus	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1944
p.R365H	SAS	upper aerodigestive tract	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1944
p.S367P	TCGA-HC-8213	PRAD	TCGA	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.25
p.G372C	DO230309	COCA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation altering degron motif	0.76
p.S366P	DO228961	LICA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation blocking phosphorylation signal	0.6667
p.S366P	DO49812	PRAD	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation blocking phosphorylation signal	0.6667
p.S369R	DO229015	LICA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.3056
p.S375I	DO45443	LUSC	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation altering degron motif	0.7341
p.P367L	DO222753	MELA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.25
p.R364H	DO42673	UCEC	ICGC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1667
p.R364H	ACH-000488	Esophageal Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1667
p.R364H	ACH-002029	Head and Neck Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1667
p.R364H	SAS	upper aerodigestive tract	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1667
p.R364H	TE-11	oesophagus	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1667
p.S363L	SIDM00333	Endometrial Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1389
p.S363L	MFE-319	endometrium	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1389
p.S362L	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1111
p.S362L	MFE-319	endometrium	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1111
p.T382A	GP5d	large intestine	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	370:375	Mutation rewiring degron network	0.1389

Kaplan plot for RAPGEF1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPGEF1

UniProt ID: Q13905

Entrez ID: 2889

Protein name: Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RAPGEF1 in