DegronMD

Uniprot ID: Q13905

Source protein: Rap guanine nucleotide exchange factor 1

Source gene: RAPGEF1

Class: DEG_SCF_TRCP1_1

Location: 370:375

E3 ligase: BTRC

DEGRON score: 0.9973

ASA_SCORE: 77.9

COIL: 0.8387

CONS_SCORE: 0.2803

DSS_SCORE: 0.4773

HELIX: 0.1152

FCONS_SCORE: 0.8513

RIG_SCORE: 0.6269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S376I	TCGA-85-8479	LUSC	TCGA	DSGQCS	DEG_SCF_TRCP1_1	0.3056
p.R365H	TCGA-AP-A051	UCEC	TCGA	DSGQCS	DEG_SCF_TRCP1_1	0.1944
p.R365H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	0.1944
p.R365H	SIDM00351	Oral Cavity Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	0.1944
p.R365H	TE-11	oesophagus	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1944
p.R365H	SAS	upper_aerodigestive_tract	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1944
p.S367P	TCGA-HC-8213	PRAD	TCGA	DSGQCS	DEG_SCF_TRCP1_1	0.25
p.G372C	DO230309	COCA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.76
p.S366P	DO228961	LICA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.6667
p.S366P	DO49812	PRAD	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.6667
p.S369R	DO229015	LICA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.3056
p.S375I	DO45443	LUSC	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.7341
p.P367L	DO222753	MELA	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.25
p.R364H	DO42673	UCEC	ICGC	DSGQCS	DEG_SCF_TRCP1_1	0.1667
p.R364H	ACH-000488	Esophageal Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	0.1667
p.R364H	ACH-002029	Head and Neck Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	0.1667
p.R364H	SAS	upper_aerodigestive_tract	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1667
p.R364H	TE-11	oesophagus	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1667
p.S363L	SIDM00333	Endometrial Carcinoma	GDSC	DSGQCS	DEG_SCF_TRCP1_1	0.1389
p.S363L	MFE-319	endometrium	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1389
p.S362L	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGQCS	DEG_SCF_TRCP1_1	0.1111
p.S362L	MFE-319	endometrium	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1111
p.T382A	GP5d	large_intestine	COSMIC	DSGQCS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13905	Rap guanine nucleotide exchange factor 1	DEG_SCF_TRCP1_1	370:375	DSGQCS	BTRC	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons