DegronMD - Q14002(CEACAM7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y140C	TCGA-13-1498	OV	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.5976
p.Y140C	DO30180	OV	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.5976
p.V131L	TCGA-17-Z005	LUAD	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1111
p.N132H	TCGA-78-7156	LUAD	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1389
p.N132H	DO23720	LUAD	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1389
p.S143L	TCGA-AJ-A3BH	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6556
p.S143L	DO228181	PBCA	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6556
p.S143L	DO41638	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6556
p.L130I	TCGA-BS-A0UF	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.0833
p.L130I	DO41488	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.0833
p.E134K	TCGA-DF-A2KU	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1944
p.E134K	DO223286	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1944
p.N154S	TCGA-ER-A42L	SKCM	TCGA	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.0556
p.N154S	DO223910	SKCM	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.0556
p.S152N	DO230312	COCA	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1111
p.N153K	DO229025	LICA	ICGC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.0833
p.F142L	SIDM00993	Plasma Cell Myeloma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00234	Other Solid Cancers	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00304	Ovarian Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00057	Neuroblastoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00589	Oral Cavity Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00552	Rhabdomyosarcoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00562	Breast Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00585	Hepatocellular Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00375	Head and Neck Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00242	Osteosarcoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM00280	Gastric Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM01609	Endometrial Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.F142L	SIDM01574	Plasma Cell Myeloma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation altering degron motif	0.6981
p.S149P	SIDM00284	Melanoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1944
p.S149P	COLO-679	skin	COSMIC	FYVFSE	LIG_APCC_ABBA_1	139:144	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEACAM7

UniProt ID: Q14002

Entrez ID: 1087

Protein name: Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEACAM7 in