DegronMD

Uniprot ID: Q14002

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 7

Source gene: CEACAM7

Class: LIG_APCC_ABBA_1

Location: 139:144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5962

ASA_SCORE: 48.6833

COIL: 0.4762

CONS_SCORE: 0.5196

DSS_SCORE: 0.3443

HELIX: 0.0293

FCONS_SCORE: 1.0348

RIG_SCORE: 0.8452

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y140C	TCGA-13-1498	OV	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.5976
p.Y140C	DO30180	OV	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.5976
p.V131L	TCGA-17-Z005	LUAD	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.1111
p.N132H	TCGA-78-7156	LUAD	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.1389
p.N132H	DO23720	LUAD	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.1389
p.S143L	TCGA-AJ-A3BH	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.6556
p.S143L	DO228181	PBCA	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.6556
p.S143L	DO41638	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.6556
p.L130I	TCGA-BS-A0UF	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.0833
p.L130I	DO41488	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.0833
p.E134K	TCGA-DF-A2KU	UCEC	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.1944
p.E134K	DO223286	UCEC	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.1944
p.N154S	TCGA-ER-A42L	SKCM	TCGA	FYVFSE	LIG_APCC_ABBA_1	0.0556
p.N154S	DO223910	SKCM	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.0556
p.S152N	DO230312	COCA	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.1111
p.N153K	DO229025	LICA	ICGC	FYVFSE	LIG_APCC_ABBA_1	0.0833
p.F142L	SIDM00993	Plasma Cell Myeloma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00234	Other Solid Cancers	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00304	Ovarian Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00057	Neuroblastoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00589	Oral Cavity Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00552	Rhabdomyosarcoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00562	Breast Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00585	Hepatocellular Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00375	Head and Neck Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00242	Osteosarcoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM00280	Gastric Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM01609	Endometrial Carcinoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.F142L	SIDM01574	Plasma Cell Myeloma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.6981
p.S149P	SIDM00284	Melanoma	GDSC	FYVFSE	LIG_APCC_ABBA_1	0.1944
p.S149P	COLO-679	skin	COSMIC	FYVFSE	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FYVFSE

Degron related mutations and impact score

Drug responses associated with CEACAM7 mutations

All proteins holding degron of FYVFSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14002	Carcinoembryonic antigen-related cell adhesion molecule 7	LIG_APCC_ABBA_1	139:144	FYVFSE	APC,CDC20,FZR1	0.5962	More...