DegronMD - Q14134(TRIM29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A122D	TCGA-05-4396	LUAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1667
p.A122D	DO23838	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1667
p.R128C	TCGA-66-2768	LUSC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.8301
p.R128C	DO27216	LUSC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.8301
p.P118H	TCGA-75-5146	LUAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0556
p.P118H	DO25228	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0556
p.E123K	TCGA-CA-6717	COAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1944
p.E123K	TCGA-Z2-A8RT	SKCM	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1944
p.E123K	DO8264	COAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1944
p.E123K	DO51301	SKCM	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1944
p.L127V	TCGA-D1-A15X	UCEC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.3056
p.L127V	DO43274	UCEC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.3056
p.S133L	TCGA-DD-A73D	LIHC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	DO48528	LIHC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	SIDM00781	Colorectal Carcinoma	GDSC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	SIDM00780	Colorectal Carcinoma	GDSC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	ACH-000967	Colon/Colorectal Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	ACH-001199	Colon/Colorectal Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.S133L	SNU-C2B	large intestine	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.7667
p.V119I	TCGA-EO-A22U	UCEC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0833
p.V119I	DO43755	UCEC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0833
p.R136Q	TCGA-FR-A8YC	SKCM	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.2778
p.R136Q	DO50301	SKCM	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.2778
p.R128H	TCGA-XK-AAIW	PRAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.8244
p.R128H	DO51407	PRAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation altering degron motif	0.8244
p.M143T	DO222905	BTCA	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0833
p.A120S	DO24227	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1111
p.G141W	DO26710	LUSC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation blocking phosphorylation signal	0.5833
p.T120P	DO49418	PACA	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.1111
p.E119K	ACH-000204	Myeloma	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0833
p.E119K	LP-1	haematopoietic and lymphoid tissue	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0833
p.N118S	ACH-002234	Head and Neck Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0556
p.N118S	DOK	upper aerodigestive tract	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.0556
p.H136Y	IGR-37	skin	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	128:134	Mutation rewiring degron network	0.2778

Kaplan plot for TRIM29 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM29

UniProt ID: Q14134

Entrez ID: 23650

Protein name: Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM29 in