DegronMD

Uniprot ID: Q14134

Source protein: Tripartite motif-containing protein 29

Source gene: TRIM29

Class: LIG_APCC_ABBAyCdc20_2

Location: 128:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.987

ASA_SCORE: 75.4857

COIL: 0.5749

CONS_SCORE: 0.7826

DSS_SCORE: 0.47

HELIX: 0.1666

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7391

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A122D	TCGA-05-4396	LUAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A122D	DO23838	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R128C	TCGA-66-2768	LUSC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R128C	DO27216	LUSC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.P118H	TCGA-75-5146	LUAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P118H	DO25228	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E123K	TCGA-CA-6717	COAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E123K	TCGA-Z2-A8RT	SKCM	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E123K	DO8264	COAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E123K	DO51301	SKCM	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L127V	TCGA-D1-A15X	UCEC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L127V	DO43274	UCEC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S133L	TCGA-DD-A73D	LIHC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	DO48528	LIHC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	SIDM00781	Colorectal Carcinoma	GDSC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	SIDM00780	Colorectal Carcinoma	GDSC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	ACH-000967	Colon/Colorectal Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	ACH-001199	Colon/Colorectal Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S133L	SNU-C2B	large_intestine	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.V119I	TCGA-EO-A22U	UCEC	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V119I	DO43755	UCEC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R136Q	TCGA-FR-A8YC	SKCM	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R136Q	DO50301	SKCM	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R128H	TCGA-XK-AAIW	PRAD	TCGA	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R128H	DO51407	PRAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.M143T	DO222905	BTCA	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A120S	DO24227	LUAD	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G141W	DO26710	LUSC	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.5833
p.T120P	DO49418	PACA	ICGC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E119K	ACH-000204	Myeloma	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E119K	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N118S	ACH-002234	Head and Neck Cancer	CCLE	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N118S	DOK	upper_aerodigestive_tract	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.H136Y	IGR-37	skin	COSMIC	RKSIFSE	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKSIFSE

Degron related mutations and impact score

Drug responses associated with TRIM29 mutations

All proteins holding degron of RKSIFSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14134	Tripartite motif-containing protein 29	LIG_APCC_ABBAyCdc20_2	128:134	RKSIFSE	APC,CDC20,FZR1	0.987	More...