DegronMD - Q14153(FAM53B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D365N	TCGA-06-5416	GBM	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1111
p.D365N	DO10880	GBM	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1111
p.A351T	TCGA-EY-A549	UCEC	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation altering degron motif	0.6028
p.A351T	TCGA-N7-A4Y0	UCS	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation altering degron motif	0.6028
p.A351T	DO48174	UCEC	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation altering degron motif	0.6028
p.V355G	TCGA-L6-A4EU	THCA	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation altering degron motif	0.6421
p.V355G	DO38942	THCA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation altering degron motif	0.6421
p.S341L	TCGA-UF-A7JV	HNSC	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.0833
p.S341L	DO50010	HNSC	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.0833
p.D364G	DO50684	ORCA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1389
p.G346W	DO49204	PACA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.2222
p.G344D	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1667
p.G344D	ACH-000557	Leukemia	CCLE	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1667
p.G344D	ACH-001738	Leukemia	CCLE	PAGTPVPE	DEG_SCF_FBW7_2	350:357	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons