DegronMD

Uniprot ID: Q14153

Source protein: Protein FAM53B

Source gene: FAM53B

Class: DEG_SCF_FBW7_2

Location: 350:357

E3 ligase: FBXW7

DEGRON score: 0.9896

ASA_SCORE: 84.5125

COIL: 0.9393

CONS_SCORE: 0.3572

DSS_SCORE: 0.7475

HELIX: 0.0133

FCONS_SCORE: 1.0681

RIG_SCORE: 0.5852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D365N	TCGA-06-5416	GBM	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	0.1111
p.D365N	DO10880	GBM	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.1111
p.A351T	TCGA-EY-A549	UCEC	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	0.6028
p.A351T	TCGA-N7-A4Y0	UCS	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	0.6028
p.A351T	DO48174	UCEC	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.6028
p.V355G	TCGA-L6-A4EU	THCA	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	0.6421
p.V355G	DO38942	THCA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.6421
p.S341L	TCGA-UF-A7JV	HNSC	TCGA	PAGTPVPE	DEG_SCF_FBW7_2	0.0833
p.S341L	DO50010	HNSC	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.0833
p.D364G	DO50684	ORCA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.1389
p.G346W	DO49204	PACA	ICGC	PAGTPVPE	DEG_SCF_FBW7_2	0.2222
p.G344D	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PAGTPVPE	DEG_SCF_FBW7_2	0.1667
p.G344D	ACH-000557	Leukemia	CCLE	PAGTPVPE	DEG_SCF_FBW7_2	0.1667
p.G344D	ACH-001738	Leukemia	CCLE	PAGTPVPE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14153	Protein FAM53B	DEG_SCF_FBW7_2	350:357	PAGTPVPE	FBXW7	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons