DegronMD - Q14155(ARHGEF7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D754Y	TCGA-56-5898	LUSC	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754Y	DO26548	LUSC	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.R758H	TCGA-AA-3811	COAD	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.7133
p.R758H	DO7962	COAD	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.7133
p.R759H	TCGA-BR-4201	STAD	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	DO33105	PACA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	DO38707	STAD	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	HCT-15	large intestine	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.S774C	TCGA-K4-A6FZ	BLCA	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.1111
p.S774C	DO44045	BLCA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.1111
p.R764L	DO228948	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.7316
p.E766D	DO229038	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.5647
p.E766D	DO229008	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.5647
p.G757R	DO50970	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.3056
p.R758C	SIDM02015	Colorectal Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.719
p.R758C	Farage	haematopoietic and lymphoid tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.719
p.R758C	MHH-ES-1	bone	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.719
p.D754E	SIDM00845	Burkitt's Lymphoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754E	SIDM00461	Acute Myeloid Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754E	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754E	SIDM01519	Head and Neck Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754E	NCI-H441	lung	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.D754E	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.2222
p.T769A	SIDM00845	Burkitt's Lymphoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.25
p.T769A	SIDM00461	Acute Myeloid Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.25
p.T769A	SIDM01519	Head and Neck Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.25
p.I749V	KMH-2	thyroid	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.D775E	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.D775E	NCI-H441	lung	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833

Kaplan plot for ARHGEF7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF7

UniProt ID: Q14155

Entrez ID: 8874

Protein name: Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF7 in