DegronMD

Uniprot ID: Q14155

Source protein: Rho guanine nucleotide exchange factor 7

Source gene: ARHGEF7

Class: DEG_APCC_DBOX_1

Location: 758:766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9889

ASA_SCORE: 97.8778

COIL: 0.7247

CONS_SCORE: 0.3705

DSS_SCORE: 0.5092

HELIX: 0.1623

FCONS_SCORE: 1.1828

RIG_SCORE: 0.6592

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D754Y	TCGA-56-5898	LUSC	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754Y	DO26548	LUSC	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.R758H	TCGA-AA-3811	COAD	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	0.7133
p.R758H	DO7962	COAD	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.7133
p.R759H	TCGA-BR-4201	STAD	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	0.8244
p.R759H	DO33105	PACA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.8244
p.R759H	DO38707	STAD	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.8244
p.R759H	HCT-15	large_intestine	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.8244
p.S774C	TCGA-K4-A6FZ	BLCA	TCGA	RRSSLSRLE	DEG_APCC_DBOX_1	0.1111
p.S774C	DO44045	BLCA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.1111
p.R764L	DO228948	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.7316
p.E766D	DO229038	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.5647
p.E766D	DO229008	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.5647
p.G757R	DO50970	LICA	ICGC	RRSSLSRLE	DEG_APCC_DBOX_1	0.3056
p.R758C	SIDM02015	Colorectal Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.719
p.R758C	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.719
p.R758C	MHH-ES-1	bone	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.719
p.D754E	SIDM00845	Burkitt's Lymphoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754E	SIDM00461	Acute Myeloid Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754E	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754E	SIDM01519	Head and Neck Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754E	NCI-H441	lung	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.D754E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.2222
p.T769A	SIDM00845	Burkitt's Lymphoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.25
p.T769A	SIDM00461	Acute Myeloid Leukemia	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.25
p.T769A	SIDM01519	Head and Neck Carcinoma	GDSC	RRSSLSRLE	DEG_APCC_DBOX_1	0.25
p.I749V	KMH-2	thyroid	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.0833
p.D775E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.0833
p.D775E	NCI-H441	lung	COSMIC	RRSSLSRLE	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSSLSRLE

Degron related mutations and impact score

Drug responses associated with ARHGEF7 mutations

All proteins holding degron of RRSSLSRLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14155	Rho guanine nucleotide exchange factor 7	DEG_APCC_DBOX_1	758:766	RRSSLSRLE	APC,CDC20,FZR1	0.9889	More...