DegronMD - Q14166(TTLL12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H303R	DO228324	BRCA	ICGC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2778
p.V314L	DO224563	LUSC	ICGC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2222
p.T309M	DO229240	THCA	ICGC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7423
p.D310Y	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7325
p.D310Y	ACH-000924	Lung Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7325
p.D310Y	NCI-H2172	lung	COSMIC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7325
p.T319I	SIDM00656	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation blocking phosphorylation signal	0.5278
p.T319I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation blocking phosphorylation signal	0.5278
p.T319I	SIDM00844	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation blocking phosphorylation signal	0.5278
p.T319I	SIDM00641	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation blocking phosphorylation signal	0.5278
p.G302S	SIDM00282	Colorectal Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25
p.G302S	ACH-000019	Breast Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25
p.G302S	ACH-000028	Breast Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25
p.G302S	ACH-000998	Colon/Colorectal Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons