DegronMD

Uniprot ID: Q14166

Source protein: Tubulin--tyrosine ligase-like protein 12

Source gene: TTLL12

Class: LIG_APCC_ABBA_1

Location: 305:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9518

ASA_SCORE: 69.9333

COIL: 0.63

CONS_SCORE: 0.5412

DSS_SCORE: 0.2523

HELIX: 0.1992

FCONS_SCORE: 1.3487

RIG_SCORE: 0.8495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H303R	DO228324	BRCA	ICGC	FKVYTD	LIG_APCC_ABBA_1	0.2778
p.V314L	DO224563	LUSC	ICGC	FKVYTD	LIG_APCC_ABBA_1	0.2222
p.T309M	DO229240	THCA	ICGC	FKVYTD	LIG_APCC_ABBA_1	0.7423
p.D310Y	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.7325
p.D310Y	ACH-000924	Lung Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	0.7325
p.D310Y	NCI-H2172	lung	COSMIC	FKVYTD	LIG_APCC_ABBA_1	0.7325
p.T319I	SIDM00656	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.5278
p.T319I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.5278
p.T319I	SIDM00844	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.5278
p.T319I	SIDM00641	Burkitt's Lymphoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.5278
p.G302S	SIDM00282	Colorectal Carcinoma	GDSC	FKVYTD	LIG_APCC_ABBA_1	0.25
p.G302S	ACH-000019	Breast Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	0.25
p.G302S	ACH-000028	Breast Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	0.25
p.G302S	ACH-000998	Colon/Colorectal Cancer	CCLE	FKVYTD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14166	Tubulin--tyrosine ligase-like protein 12	LIG_APCC_ABBA_1	305:310	FKVYTD	APC,CDC20,FZR1	0.9518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons