DegronMD - Q14183(DOC2A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V155L	TCGA-53-7813	LUAD	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.V155L	DO24349	LUAD	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.G164E	TCGA-EE-A2GC	SKCM	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.1111
p.G164E	DO37839	SKCM	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.1111
p.P154L	TCGA-FW-A3R5	SKCM	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.6471
p.P154L	DO37406	SKCM	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.6471
p.I165F	TCGA-VR-AA7D	ESCA	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0833
p.T145K	DO228976	LICA	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.K146T	DO51548	PACA	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.2778
p.S163R	SIDM00871	Non-Cancerous	GDSC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.1389
p.S163R	SIDM00872	Breast Carcinoma	GDSC	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.1389
p.D159N	ACH-001558	Lung Cancer	CCLE	QRNTLNPVW	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons