DegronMD

Uniprot ID: Q14183

Source protein: Double C2-like domain-containing protein alpha

Source gene: DOC2A

Class: DEG_APCC_DBOX_1

Location: 148:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7348

ASA_SCORE: 75.4667

COIL: 0.7

CONS_SCORE: 0.6854

DSS_SCORE: 0.35

HELIX: 0.0156

FCONS_SCORE: 1.2485

RIG_SCORE: 0.802

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P154L	TCGA-FW-A3R5	SKCM	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	0.6471
p.P154L	DO37406	SKCM	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	0.6471
p.V155L	TCGA-53-7813	LUAD	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	0.5654
p.V155L	DO24349	LUAD	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	0.5654
p.K146T	DO51548	PACA	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	0.2778
p.T145K	DO228976	LICA	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	0.25
p.D159N	ACH-001558	Lung Cancer	CCLE	QRNTLNPVW	DEG_APCC_DBOX_1	0.25
p.S163R	SIDM00871	Non-Cancerous	GDSC	QRNTLNPVW	DEG_APCC_DBOX_1	0.1389
p.S163R	SIDM00872	Breast Carcinoma	GDSC	QRNTLNPVW	DEG_APCC_DBOX_1	0.1389
p.G164E	TCGA-EE-A2GC	SKCM	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	0.1111
p.G164E	DO37839	SKCM	ICGC	QRNTLNPVW	DEG_APCC_DBOX_1	0.1111
p.I165F	TCGA-VR-AA7D	ESCA	TCGA	QRNTLNPVW	DEG_APCC_DBOX_1	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14183	Double C2-like domain-containing protein alpha	DEG_APCC_DBOX_1	148:156	QRNTLNPVW	APC,CDC20,FZR1	0.7348	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons