DegronMD - Q14206(RCAN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E116K	TCGA-85-A50M	LUSC	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1944
p.I102T	TCGA-DU-6392	LGG	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7078
p.R101S	TCGA-EE-A181	SKCM	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7427
p.Q92K	TCGA-EE-A2GN	SKCM	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1111
p.S109F	TCGA-IF-A4AJ	SARC	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7982
p.E119K	TCGA-XF-AAN3	BLCA	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1111
p.Q121R	TCGA-ZF-A9RC	BLCA	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.0556
p.L110I	DO6308	CESC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.6063
p.S115T	DO223093	ESCA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.2222
p.P103H	DO228952	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.6583
p.P102T	DO228971	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7031
p.P105T	DO229035	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.5919
p.P113T	DO229009	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.2778
p.P117Q	DO229008	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1667
p.D94Y	DO27492	LUSC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1667
p.S116F	DO222702	MELA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1944
p.L110F	DO37406	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.587
p.P117L	DO50299	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1667
p.Q104H	DO47578	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.647
p.E92K	DO51266	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.1111
p.S112L	DO41644	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.3056
p.S115P	DO41903	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.2222
p.A101D	DO42673	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7793
p.R101C	SIDM02058	Esophageal Carcinoma	GDSC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.8301
p.W121G	ACH-000621	Breast Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.0556
p.W121G	MDA-MB-157	breast	COSMIC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation rewiring degron network	0.0556
p.A101V	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.6936
p.A101V	HT-115	large intestine	COSMIC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.6936
p.P102Q	ACH-002017	Eye Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	100:111	Mutation altering degron motif	0.7035

Kaplan plot for RCAN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RCAN2

UniProt ID: Q14206

Entrez ID: 10231

Protein name: Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RCAN2 in