DegronMD

Uniprot ID: Q14206

Source protein: Calcipressin-2

Source gene: RCAN2

Class: DEG_ODPH_VHL_1

Location: 100:111

E3 ligase: VHL

DEGRON score: 0.9934

ASA_SCORE: 69.1917

COIL: 0.7361

CONS_SCORE: 0.7488

DSS_SCORE: 0.5939

HELIX: 0.1891

FCONS_SCORE: 1.0993

RIG_SCORE: 0.7031

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E116K	TCGA-85-A50M	LUSC	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1944
p.I102T	TCGA-DU-6392	LGG	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7078
p.R101S	TCGA-EE-A181	SKCM	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7427
p.Q92K	TCGA-EE-A2GN	SKCM	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1111
p.S109F	TCGA-IF-A4AJ	SARC	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7982
p.E119K	TCGA-XF-AAN3	BLCA	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1111
p.Q121R	TCGA-ZF-A9RC	BLCA	TCGA	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.0556
p.L110I	DO6308	CESC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.6063
p.S115T	DO223093	ESCA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.2222
p.P103H	DO228952	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.6583
p.P102T	DO228971	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7031
p.P105T	DO229035	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.5919
p.P113T	DO229009	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.2778
p.P117Q	DO229008	LICA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1667
p.D94Y	DO27492	LUSC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1667
p.S116F	DO222702	MELA	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1944
p.L110F	DO37406	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.587
p.P117L	DO50299	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1667
p.Q104H	DO47578	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.647
p.E92K	DO51266	SKCM	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.1111
p.S112L	DO41644	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.3056
p.S115P	DO41903	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.2222
p.A101D	DO42673	UCEC	ICGC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7793
p.R101C	SIDM02058	Esophageal Carcinoma	GDSC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.8301
p.W121G	ACH-000621	Breast Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.0556
p.W121G	MDA-MB-157	breast	COSMIC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.0556
p.A101V	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.6936
p.A101V	HT-115	large_intestine	COSMIC	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.6936
p.P102Q	ACH-002017	Eye Cancer	CCLE	LAPPQPAKQFLI	DEG_ODPH_VHL_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPQPAKQFLI

Degron related mutations and impact score

Drug responses associated with RCAN2 mutations

All proteins holding degron of LAPPQPAKQFLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14206	Calcipressin-2	DEG_ODPH_VHL_1	100:111	LAPPQPAKQFLI	VHL	0.9934	More...