DegronMD - Q14324(MYBPC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T737K	TCGA-58-A46N	LUSC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6195
p.T737K	DO45460	LUSC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6195
p.D747N	TCGA-AP-A051	UCEC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2778
p.D747N	DO42673	UCEC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2778
p.N727D	TCGA-DD-AADV	LIHC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1389
p.N727D	DO219573	LIHC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1389
p.S738G	TCGA-F5-6814	READ	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.5882
p.S738G	DO36556	READ	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.5882
p.S738G	SIDM00060	Ovarian Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.5882
p.T753N	TCGA-FI-A2D5	UCEC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1111
p.T753N	DO41331	UCEC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1111
p.D750N	TCGA-FS-A1ZD	SKCM	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1944
p.D750N	DO37627	SKCM	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.1944
p.E739K	TCGA-FS-A4F5	SKCM	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.591
p.E739K	DO37881	SKCM	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.591
p.K729N	DO229029	LICA	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation substituting flanking lysine	0.3056
p.P730S	SIDM00955	Melanoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.P730S	ACH-000812	Skin Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.P730S	COLO-783	skin	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.P730L	SIDM00885	Breast Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.P730L	ACH-000111	Breast Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.P730L	HCC1187	breast	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation rewiring degron network	0.2222
p.I734L	SIDM00202	Ewing's Sarcoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6063
p.I734L	SIDM01323	Oral Cavity Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6063
p.I744T	SIDM01114	Non-Cancerous	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.5966
p.P740A	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6392
p.P740A	ACH-000869	Lung Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6392
p.P740A	NCI-H1568	lung	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	734:745	Mutation altering degron motif	0.6392

Kaplan plot for MYBPC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBPC2

UniProt ID: Q14324

Entrez ID: 4606

Protein name: Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBPC2 in