DegronMD

Uniprot ID: Q14324

Source protein: Myosin-binding protein C, fast-type

Source gene: MYBPC2

Class: DEG_ODPH_VHL_1

Location: 734:745

E3 ligase: VHL

DEGRON score: 0.991

ASA_SCORE: 76.4917

COIL: 0.7769

CONS_SCORE: 0.5436

DSS_SCORE: 0.3859

HELIX: 0.0113

FCONS_SCORE: 1.003

RIG_SCORE: 0.7633

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T737K	TCGA-58-A46N	LUSC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6195
p.T737K	DO45460	LUSC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6195
p.D747N	TCGA-AP-A051	UCEC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2778
p.D747N	DO42673	UCEC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2778
p.N727D	TCGA-DD-AADV	LIHC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1389
p.N727D	DO219573	LIHC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1389
p.S738G	TCGA-F5-6814	READ	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.5882
p.S738G	DO36556	READ	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.5882
p.S738G	SIDM00060	Ovarian Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.5882
p.T753N	TCGA-FI-A2D5	UCEC	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1111
p.T753N	DO41331	UCEC	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1111
p.D750N	TCGA-FS-A1ZD	SKCM	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1944
p.D750N	DO37627	SKCM	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.1944
p.E739K	TCGA-FS-A4F5	SKCM	TCGA	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.591
p.E739K	DO37881	SKCM	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.591
p.K729N	DO229029	LICA	ICGC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.3056
p.P730S	SIDM00955	Melanoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.P730S	ACH-000812	Skin Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.P730S	COLO-783	skin	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.P730L	SIDM00885	Breast Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.P730L	ACH-000111	Breast Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.P730L	HCC1187	breast	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.2222
p.I734L	SIDM00202	Ewing's Sarcoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6063
p.I734L	SIDM01323	Oral Cavity Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6063
p.I744T	SIDM01114	Non-Cancerous	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.5966
p.P740A	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6392
p.P740A	ACH-000869	Lung Cancer	CCLE	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6392
p.P740A	NCI-H1568	lung	COSMIC	IAPTSEPLHLIV	DEG_ODPH_VHL_1	0.6392

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPTSEPLHLIV

Degron related mutations and impact score

Drug responses associated with MYBPC2 mutations

All proteins holding degron of IAPTSEPLHLIV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14324	Myosin-binding protein C, fast-type	DEG_ODPH_VHL_1	734:745	IAPTSEPLHLIV	VHL	0.991	More...