DegronMD - Q14439(GPR176)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P436L	TCGA-95-7567	LUAD	TCGA	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.7582
p.A437T	TCGA-DF-A2KN	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6028
p.P439L	TCGA-EE-A29E	SKCM	TCGA	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6471
p.P439L	SIDM00578	Neuroblastoma	GDSC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6471
p.P439L	ACH-000804	Neuroblastoma	CCLE	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6471
p.P439L	NB1	autonomic ganglia	COSMIC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6471
p.K448N	TCGA-EO-A22X	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	435:443	Mutation substituting flanking lysine	0.3056
p.V431A	TCGA-EO-A3B0	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	435:443	Mutation rewiring degron network	0.2222
p.Q443K	DO228544	GACA	ICGC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.6944
p.Q443H	DO220843	MELA	ICGC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.7582
p.E440K	DO220886	MELA	ICGC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.7022
p.E453K	DO50286	SKCM	ICGC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation rewiring degron network	0.0556
p.P438L	NB1	autonomic ganglia	COSMIC	APAAPVEPE	DEG_SIAH_1	435:443	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons