DegronMD

Uniprot ID: Q14439

Source protein: G-protein coupled receptor 176

Source gene: GPR176

Class: DEG_SIAH_1

Location: 435:443

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8258

ASA_SCORE: 73.7333

COIL: 0.8797

CONS_SCORE: 0.6202

DSS_SCORE: 0.4804

HELIX: 0.0624

FCONS_SCORE: 0.9394

RIG_SCORE: 0.6813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P436L	TCGA-95-7567	LUAD	TCGA	APAAPVEPE	DEG_SIAH_1	0.7582
p.A437T	TCGA-DF-A2KN	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	0.6028
p.P439L	TCGA-EE-A29E	SKCM	TCGA	APAAPVEPE	DEG_SIAH_1	0.6471
p.P439L	SIDM00578	Neuroblastoma	GDSC	APAAPVEPE	DEG_SIAH_1	0.6471
p.P439L	ACH-000804	Neuroblastoma	CCLE	APAAPVEPE	DEG_SIAH_1	0.6471
p.P439L	NB1	autonomic_ganglia	COSMIC	APAAPVEPE	DEG_SIAH_1	0.6471
p.K448N	TCGA-EO-A22X	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	0.3056
p.V431A	TCGA-EO-A3B0	UCEC	TCGA	APAAPVEPE	DEG_SIAH_1	0.2222
p.Q443K	DO228544	GACA	ICGC	APAAPVEPE	DEG_SIAH_1	0.6944
p.Q443H	DO220843	MELA	ICGC	APAAPVEPE	DEG_SIAH_1	0.7582
p.E440K	DO220886	MELA	ICGC	APAAPVEPE	DEG_SIAH_1	0.7022
p.E453K	DO50286	SKCM	ICGC	APAAPVEPE	DEG_SIAH_1	0.0556
p.P438L	NB1	autonomic_ganglia	COSMIC	APAAPVEPE	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14439	G-protein coupled receptor 176	DEG_SIAH_1	435:443	APAAPVEPE	SIAH1,SIAH2,SIAH3	0.8258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons