DegronMD - Q14563(SEMA3A)

GO - Biological processes (BP): apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; branchiomotor neuron axon guidance [GO:0021785]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neural crest cell migration involved in sympathetic nervous system development [GO:1903045]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; positive regulation of male gonad development [GO:2000020]; positive regulation of neuron migration [GO:2001224]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of heart rate [GO:0002027]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory system development [GO:0048880]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N743K	TCGA-05-5428	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation altering degron motif	0.5806
p.N743K	DO24005	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation altering degron motif	0.5806
p.D729N	TCGA-24-1927	OV	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1111
p.D729N	DO31604	OV	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1111
p.D729Y	TCGA-49-6743	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1111
p.D729Y	DO26092	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1111
p.R734L	TCGA-49-AAR4	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R734L	TCGA-MN-A4N1	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R734L	DO218920	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R734L	DO45328	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R728S	TCGA-49-AAR4	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.0833
p.R728S	DO218920	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.0833
p.W747C	TCGA-56-7221	LUSC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.W747C	DO26689	LUSC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.W747L	TCGA-56-7221	LUSC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.W747L	DO26689	LUSC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R736M	TCGA-AX-A060	UCEC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.3056
p.R736M	DO228928	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.3056
p.R736M	DO42576	UCEC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.3056
p.K748N	TCGA-BR-4184	STAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation substituting flanking lysine	0.3333
p.K748N	DO38328	STAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation substituting flanking lysine	0.3333
p.R733C	TCGA-CA-6717	COAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733C	DO8264	COAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733C	SIDM00673	Breast Carcinoma	GDSC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733C	HCC70	breast	COSMIC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733L	TCGA-DD-A1EE	LIHC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733L	TCGA-G3-A25S	LIHC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733L	DO23018	LIHC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R733L	DO22857	LIHC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.2222
p.R730Q	TCGA-GN-A266	SKCM	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1389
p.R730Q	DO37432	SKCM	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1389
p.K754M	DO228313	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation substituting flanking lysine	0.1667
p.T740N	DO229035	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation altering degron motif	0.7055
p.H749R	DO232761	PBCA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.1944
p.R734W	SIDM01611	Endometrial Carcinoma	GDSC	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25
p.R734W	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGHTPGNS	DEG_SCF_FBW7_1	737:744	Mutation rewiring degron network	0.25

Kaplan plot for SEMA3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA3A

UniProt ID: Q14563

Entrez ID: 10371

Protein name: Semaphorin-3A (Semaphorin III) (Sema III)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA3A in