DegronMD

Uniprot ID: Q14563

Source protein: Semaphorin-3A

Source gene: SEMA3A

Class: DEG_SCF_FBW7_1

Location: 737:744

E3 ligase: FBXW7

DEGRON score: 0.6382

ASA_SCORE: 89.275

COIL: 0.9126

CONS_SCORE: 0.368

DSS_SCORE: 0.7911

HELIX: 0.0659

FCONS_SCORE: 0.8355

RIG_SCORE: 0.5349

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N743K	TCGA-05-5428	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.5806
p.N743K	DO24005	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.5806
p.D729N	TCGA-24-1927	OV	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.1111
p.D729N	DO31604	OV	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.1111
p.D729Y	TCGA-49-6743	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.1111
p.D729Y	DO26092	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.1111
p.R734L	TCGA-49-AAR4	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R734L	TCGA-MN-A4N1	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R734L	DO218920	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R734L	DO45328	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R728S	TCGA-49-AAR4	LUAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.0833
p.R728S	DO218920	LUAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.0833
p.W747C	TCGA-56-7221	LUSC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.W747C	DO26689	LUSC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.W747L	TCGA-56-7221	LUSC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.W747L	DO26689	LUSC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R736M	TCGA-AX-A060	UCEC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.3056
p.R736M	DO228928	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.3056
p.R736M	DO42576	UCEC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.3056
p.K748N	TCGA-BR-4184	STAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.3333
p.K748N	DO38328	STAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.3333
p.R733C	TCGA-CA-6717	COAD	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733C	DO8264	COAD	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733C	SIDM00673	Breast Carcinoma	GDSC	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733C	HCC70	breast	COSMIC	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733L	TCGA-DD-A1EE	LIHC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733L	TCGA-G3-A25S	LIHC	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733L	DO23018	LIHC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R733L	DO22857	LIHC	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.2222
p.R730Q	TCGA-GN-A266	SKCM	TCGA	PGHTPGNS	DEG_SCF_FBW7_1	0.1389
p.R730Q	DO37432	SKCM	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.1389
p.K754M	DO228313	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.1667
p.T740N	DO229035	LICA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.7055
p.H749R	DO232761	PBCA	ICGC	PGHTPGNS	DEG_SCF_FBW7_1	0.1944
p.R734W	SIDM01611	Endometrial Carcinoma	GDSC	PGHTPGNS	DEG_SCF_FBW7_1	0.25
p.R734W	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGHTPGNS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGHTPGNS

Degron related mutations and impact score

Drug responses associated with SEMA3A mutations

All proteins holding degron of PGHTPGNS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14563	Semaphorin-3A	DEG_SCF_FBW7_1	737:744	PGHTPGNS	FBXW7	0.6382	More...