DegronMD - Q14596(NBR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P582S	TCGA-2W-A8YY	CESC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582S	DO223732	CESC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.T586I	TCGA-AJ-A23O	UCEC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.8189
p.T586I	DO43290	UCEC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.8189
p.P578S	TCGA-AX-A06F	UCEC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1944
p.P578S	DO41752	UCEC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1944
p.P582H	TCGA-DA-A1HW	SKCM	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582H	TCGA-DU-6392	LGG	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582H	DO22237	LGG	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582H	DO38129	SKCM	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582T	TCGA-EE-A2GN	SKCM	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.P582T	DO37896	SKCM	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.H579Y	DO223538	CLLE	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.V585L	DO23394	LINC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.5654
p.V585M	SIDM00845	Burkitt's Lymphoma	GDSC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.6097
p.V585M	ACH-000786	Lymphoma	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.6097
p.P597L	SIDM00003	Melanoma	GDSC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.P597L	ACH-000884	Skin Cancer	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.P597L	ACH-002159	Skin Cancer	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.P597L	M14	skin	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.E587Q	ME-180	cervix	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.6744
p.P576L	M14	skin	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389

Kaplan plot for NBR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBR1

UniProt ID: Q14596

Entrez ID: 4077

Protein name: Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBR1 in