DegronMD

Uniprot ID: Q14596

Source protein: Next to BRCA1 gene 1 protein

Source gene: NBR1

Class: DEG_SCF_FBW7_1

Location: 583:590

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 80.1375

COIL: 0.9209

CONS_SCORE: 0.3724

DSS_SCORE: 0.5464

HELIX: 0.0216

FCONS_SCORE: 1.0454

RIG_SCORE: 0.7176

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T586I	TCGA-AJ-A23O	UCEC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.8189
p.T586I	DO43290	UCEC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.8189
p.E587Q	ME-180	cervix	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	0.6744
p.V585M	SIDM00845	Burkitt's Lymphoma	GDSC	VDVTPCMS	DEG_SCF_FBW7_1	0.6097
p.V585M	ACH-000786	Lymphoma	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	0.6097
p.V585L	DO23394	LINC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.5654
p.P582S	TCGA-2W-A8YY	CESC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582S	DO223732	CESC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582H	TCGA-DA-A1HW	SKCM	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582H	TCGA-DU-6392	LGG	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582H	DO22237	LGG	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582H	DO38129	SKCM	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582T	TCGA-EE-A2GN	SKCM	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.P582T	DO37896	SKCM	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.3056
p.H579Y	DO223538	CLLE	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.2222
p.P578S	TCGA-AX-A06F	UCEC	TCGA	VDVTPCMS	DEG_SCF_FBW7_1	0.1944
p.P578S	DO41752	UCEC	ICGC	VDVTPCMS	DEG_SCF_FBW7_1	0.1944
p.P597L	SIDM00003	Melanoma	GDSC	VDVTPCMS	DEG_SCF_FBW7_1	0.1389
p.P597L	ACH-000884	Skin Cancer	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	0.1389
p.P597L	ACH-002159	Skin Cancer	CCLE	VDVTPCMS	DEG_SCF_FBW7_1	0.1389
p.P597L	M14	skin	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	0.1389
p.P576L	M14	skin	COSMIC	VDVTPCMS	DEG_SCF_FBW7_1	0.1389

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14596	Next to BRCA1 gene 1 protein	DEG_SCF_FBW7_1	583:590	VDVTPCMS	FBXW7	0.9995	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons