DegronMD - Q14623(IHH)

GO - Biological processes (BP): bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye photoreceptor cell fate commitment [GO:0060220]; cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte proliferation [GO:0035988]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint development [GO:0072498]; epithelial cell-cell adhesion [GO:0090136]; epithelial cell morphogenesis [GO:0003382]; head morphogenesis [GO:0060323]; heart looping [GO:0001947]; intein-mediated protein splicing [GO:0016539]; in utero embryonic development [GO:0001701]; liver regeneration [GO:0097421]; maternal process involved in female pregnancy [GO:0060135]; multicellular organism growth [GO:0035264]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of eye pigmentation [GO:0048074]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell differentiation in thymus [GO:0033085]; neuron development [GO:0048666]; osteoblast differentiation [GO:0001649]; pancreas development [GO:0031016]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; regulation of growth [GO:0040008]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; retinal pigment epithelium development [GO:0003406]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; smooth muscle tissue development [GO:0048745]; somite development [GO:0061053]; vitelline membrane formation [GO:0030704] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F240L	TCGA-55-8507	LUAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.F240L	DO45412	LUAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.F246L	TCGA-CK-4951	COAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation altering degron motif	0.6981
p.F246L	DO10582	COAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation altering degron motif	0.6981
p.R249H	TCGA-HJ-7597	STAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056
p.R249H	DO38195	STAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056
p.A256P	DO228390	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1111
p.P251H	DO228948	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.R249S	DO229019	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056
p.Q258K	DO229032	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.0556
p.G236V	DO34905	PACA	ICGC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1389
p.P251L	SIDM01051	Ovarian Carcinoma	GDSC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.P251L	ACH-000936	Ovarian Cancer	CCLE	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.P251L	EFO-27	ovary	COSMIC	VLIFLD	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25

Kaplan plot for IHH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IHH

UniProt ID: Q14623

Entrez ID: 3549

Protein name: Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IHH in