DegronMD

Uniprot ID: Q14623

Source protein: Indian hedgehog protein

Source gene: IHH

Class: LIG_APCC_ABBA_1

Location: 243:248

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5363

ASA_SCORE: 24.65

COIL: 0.1732

CONS_SCORE: 0.6502

DSS_SCORE: 0.2802

HELIX: 0.0313

FCONS_SCORE: 1.3295

RIG_SCORE: 0.8654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F240L	TCGA-55-8507	LUAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	0.25
p.F240L	DO45412	LUAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.25
p.F246L	TCGA-CK-4951	COAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	0.6981
p.F246L	DO10582	COAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.6981
p.R249H	TCGA-HJ-7597	STAD	TCGA	VLIFLD	LIG_APCC_ABBA_1	0.3056
p.R249H	DO38195	STAD	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.3056
p.A256P	DO228390	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.1111
p.P251H	DO228948	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.25
p.R249S	DO229019	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.3056
p.Q258K	DO229032	LICA	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.0556
p.G236V	DO34905	PACA	ICGC	VLIFLD	LIG_APCC_ABBA_1	0.1389
p.P251L	SIDM01051	Ovarian Carcinoma	GDSC	VLIFLD	LIG_APCC_ABBA_1	0.25
p.P251L	ACH-000936	Ovarian Cancer	CCLE	VLIFLD	LIG_APCC_ABBA_1	0.25
p.P251L	EFO-27	ovary	COSMIC	VLIFLD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14623	Indian hedgehog protein	LIG_APCC_ABBA_1	243:248	VLIFLD	APC,CDC20,FZR1	0.5363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons