DegronMD - Q14691(GINS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S45F	TCGA-56-8625	LUSC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation blocking phosphorylation signal	0.5556
p.S45F	DO45515	LUSC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation blocking phosphorylation signal	0.5556
p.G28V	TCGA-A5-A0G2	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.G28V	DO41235	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.A38T	TCGA-AP-A059	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.A38T	TCGA-EO-A22R	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.A38T	DO42713	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.A38T	DO41361	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.N25S	TCGA-D8-A1J8	BRCA	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.M36T	TCGA-DF-A2KU	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.7423
p.M36T	DO223286	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.7423
p.F24Y	TCGA-VQ-A8PT	STAD	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1944
p.F24Y	DO51776	STAD	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1944
p.P22S	TCGA-YJ-A8SW	PRAD	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.P22S	DO219410	PRAD	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.G19A	DO227520	ORCA	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.0556
p.E35G	SIDM01126	Small Cell Lung Carcinoma	GDSC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.6087
p.F24L	ACH-000836	Head and Neck Cancer	CCLE	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1944
p.E35K	ACH-002396	Bone Cancer	CCLE	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.591
p.E35K	Sarc9371	bone	COSMIC	LRQVLEEMK	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.591

Kaplan plot for GINS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GINS1

UniProt ID: Q14691

Entrez ID: 9837

Protein name: DNA replication complex GINS protein PSF1 (GINS complex subunit 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GINS1 in